| Synthesis of water-soluble cystine C60 derivative with catalyst and its active oxygen radical scavenging ability |
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| 作者姓名： | Zhen Hu Wen Chao Guan~* Xiang Ying Tang Li Zhen Huang Hong Xu |
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| 作者单位： | Zhen Hu Wen Chao Guan~* Xiang Ying Tang Li Zhen Huang Hong Xu Department of Chemistry，Huazhong University of Science and Technology，Wuhan 430074，China |
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| 摘 要： | A novel water-soluble cystine C_(60)derivative was synthesized in the presence of the catalyst,tetrabutylammonium hydroxide (TBAH).The product was characterized by FT-IR,UV,~1H NMR,~(13)C NMR,MS and elemental analysis.Furthermore,the scavenging ability to superoxygen anion radical O_2~(·-)and hydroxyl radical ~·OH was studied by chemiluminescence.It was found that cystine C_(60)derivative showed an excellent efficiency in eliminating superoxygen anion radical and hydroxyl radical.The 50% inhibition concentration(IC_(50))for superoxygen anion radical and hydroxyl radical were 0.167 and 0.008 mg/mL,respectively.
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| 关 键 词： | 水溶性胱氨酸C60衍生物 合成 催化剂 氧自由基清除活性 |
| 收稿时间： | 2006-04-28 |
Synthesis of water-soluble cystine C60 derivative with catalyst and its active oxygen radical scavenging ability |
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| Zhen Hu Wen Chao Guan* Xiang Ying Tang Li Zhen Huang Hong Xu.Synthesis of water-soluble cystine C60 derivative with catalyst and its active oxygen radical scavenging ability[J].Chinese Chemical Letters,2007,18(1):51-54. |
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| Authors: | Zhen Hu Wen Chao Guan Xiang Ying Tang Li Zhen Huang Hong Xu |
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| Institution: | Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China |
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| Abstract: | A novel water-soluble cystine C60 derivative was synthesized in the presence of the catalyst, tetrabutylammonium hydroxide (TBAH). The product was characterized by FT-IR, UV, 1H NMR, 13C NMR, MS and elemental analysis. Furthermore, the that cystine C60 derivative showed an excellent efficiency in eliminating superoxygen anion radical and hydroxyl radical. The 50%inhibition concentration (IC50) for superoxygen anion radical and hydroxyl radical were 0.167 and 0.008 mg/mL, respectively. |
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| Keywords: | Cystine C60 derivatives TBAH Superoxygen anion radical Hydroxyl radical Chemiluminescence |
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