Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound |
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| Authors: | Kobayashi Kenichi Fujii Yusuke Hirayama Yuichiro Kobayashi Shinichi Hayakawa Ichiro Kigoshi Hideo |
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| Institution: | Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan. |
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| Abstract: | A hybrid compound consisting of aplyronine A and mycalolide B was synthesized, and its biological activities were evaluated. The hybrid compound was found to have somewhat more potent actin-depolymerizing activity than aplyronine A. In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity. |
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