| Electrospray Ionization Mass Spectra of Amino Acid Methyl Ester 5′-Phosphoramidates of 2′,3′-Isopropylideneuridine |
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| 作者单位： | CHEN Wei-zhu {1，3}，GAO Yu-xing 1，BAI Yong-gang 1，HAN Da-xiong 1 and ZHAO Yu-fen {1，2**} 1.The Key Laboratory for Chemical Biology of Fujian Province，Department of Chemistry，College of Chemistry and Chemical Engineering，Xiamen University，Xiamen 361005，P. R. China; 2. Key Laboratory for Bioorganic Phosphorus Chemistry of the Ministry of Education，Department of Chemistry，School of Life Sciences and Engineering，Tsinghua University，Beijin 100084，P. R. China; 3. The Third Institute of Oceanography of the State Oceanic Administration，Xiamen 361005，P. R. China |
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| 基金项目： | Supported by the National Natural Science Foundation of China(No.20572061). |
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| 摘 要： | IntroductionIn recent years, nucleosides and their analogshave been extensively studied as potential anticancerand antiviral agents[1—3]. For example, several purineand pyridine bases and nucleoside analogs are used aschemotherapeutic arsenal. For their biological activity,these analogs should be intracellularly metabolized to5′-mononucleotides by kinase-mediated phosphoryla-tion[4]. To overcome the problemof drug resistance andto improve the membrane penetration, a series of aminoacid phosp…
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| 关 键 词： | ESIMS Fragmentation pathway Methoxy group rearrangement Pentacoordinated phosphorus intermediate Amino acid methyl ester 5′-phosphoramidate of nucleoside |
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