Bifunctional organocatalyst for methanolytic desymmetrization of cyclic anhydrides: increasing enantioselectivity by catalyst dilution |
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| Authors: | Rho Ho Sik Oh Sang Ho Lee Ji Woong Lee Jin Yong Chin Jik Song Choong Eui |
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| Affiliation: | Department of Chemistry, Sungkyunkwan University, 300 Cheoncheon, Jangan, Suwon, Gyeonggi, 440-746 Korea. |
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| Abstract: | Highly enantioselective methanolysis of meso-cyclic anhydride was achieved with bifunctional organocatalyst containing a quinine-thiourea moiety; unusual concentration, temperature and solvent effects on the enantioselectivity can be explained in terms of a mechanism involving monomer-dimer equilibration of the catalyst. |
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