| Synthesis,Crystal Structure and Antitumor Activities of Ethyl 5-methyl-4-morpholino- 2-（3-Methyl-phenylamino）-furo [2,3-d] pyrimidine-6-carboxylate |
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| 作者姓名： | LI Yan TANG He-Xin GAO Hai-Tao HU Yang-Gen |
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| 作者单位： | [1]School of Nuclear Technology ＆ Chemistry and Biology, Hubei University of Science and Technology, Xianning 437100, China [2]Institute of Synthetic Organic and Medicinal Chemistry, Hubei University of Medicine, Shiyan 442000, China [3]Taihe Hospital of Hubei University of Medicine, Shiyan 442000, China |
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| 基金项目： | The project was supported by the Natural Science Foundation of Hubei Provincial Department of Science and Technology （No. 2011CDB08301 ） and the Science Research Project of Hubei University of Medicine （No. 2011 CXX03 and 2009QDJ15） |
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| 摘 要： | The title compound （C21H24N4O4, Mr = 396.44） has been synthesized by the func- tionalized ethyl 4-chloro-6-methyl-2-arylamino-furo2,3-d]pyrimidine-5-carboxylates and mor- pholine. Its structure was confirmed by means of 1H NMR IR, MS and elemental analysis. The crystal structure of the title compound was determined by X-ray single-crystal diffraction. The compound crystallizes in triclinic system, space group P1, a = 7.9919（8）, b = 9.9312（1）, c = 12.9380（13） A, aα = 86.987（2）, β = 83.604（2）, γ = 89.641（2）°, V = 1019.08（18） A3, Z = 2, F（000） = 420, Dc = 1.292 g/cm3,μ = 0.091 mm-1, R = 0.0602 and wR = 0.1548 for 3943 independent （Rint = 0.0639） and 3414 observed （I 〉 2σ（I）） reflections, lntermolecular N-H…O and π-π stacking interactions contributed to the stability of the structure. The preliminary biological test indicated the title compound exhibited cytotoxicity against human lung cancer cell lines.
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| 关 键 词： | 抗肿瘤活性 结构 羧酸乙酯 合成 乙基 氨基 呋喃 嘧啶 |
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