Synthesis of n2-alkyl(aryl,dialkyl, cycloalkyl)guanines

Novel N²-alkyl(aryl, dialkyl, cycloalkyl)guanines have been synthesized by treating 2-chloro-7-benzylhypozanthine with amines and debenzylation of the N²-substituted 7-benzylguanine products by means of palladium catalyzed hydrogenation.DeceasedCenter for the Chemistry of Medicinal Compounds. All Russian Chemico-Pharmaceutical Science Research Institute, Moscow, 119815. State Institute for Blood Substitutes and Medicinal Preparations, Moscow, 109044. Zaporozh'e State Medicinal Institute, Zaporozhe'e, 330074. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 391–394, March, 1996. Original article submitted January 6, 1996.