Hemiaminals as substrates for sulfur ylides: direct asymmetric syntheses of functionalised pyrrolidines and piperidines |
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Authors: | Kokotos Christoforos G Aggarwal Varinder K |
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Affiliation: | School of Chemistry, University of Bristol, Bristol, UKBS8 1TS. |
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Abstract: | Phenyl stabilised chiral sulfur ylides react with five-membered-ring hemiaminals to give functionalised pyrrolidines directly with high enantioselectivity. The reaction can be diverted to give piperidines instead by isolation of the intermediate epoxide and treatment with TMSOTf. |
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