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The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2 |
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| Authors: | Andrey A. Ivashchenko Bogdan A. Zagribelnyy Yan A. Ivanenkov Ilya A. Ivashchenko Ruben N. Karapetian Dmitry V. Kravchenko Nikolay P. Savchuk Elena V. Yakubova Alexandre V. Ivachtchenko |
| Affiliation: | 1.ChemDiv Inc., San Diego, CA 92130, USA;2.Viriom Inc., San Diego, CA 92130, USA;3.ASAVI LLC, 1835 E. Hallandale Beach Blvd, #442, Hallandale Beach, FL 33009, USA |
| Abstract: | The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in increasing the survival rate were demonstrated. This preclinical study can be considered a confirmatory step before introducing the combinations into clinical assessment. |
| Keywords: | aprotinin antiviral drugs SARS-CoV-2 COVID-19 influenza |