| 2位取代嘌呤衍生物的合成研究 |
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| 引用本文： | 刘福胜,于世涛,葛晓萍,杨锦宗.2位取代嘌呤衍生物的合成研究[J].高等学校化学学报,2003,24(9):1592-1598. |
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| 作者姓名： | 刘福胜 于世涛 葛晓萍 杨锦宗 |
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| 作者单位： | 1. 青岛科技大学化工学院, 青岛 266042;
2. 大连理工大学精细化工国家重点实验室, 大连 116012 |
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| 基金项目： | 山东省优秀中青年科学家科学研究奖励基金(批准号:02135107) |
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| 摘 要： | 对2-碘-9-苄基嘌呤与有机锡试剂RSnBu3之间的Stille偶合反应以及2-乙烯基-9-苄基嘌呤中的乙烯基的亲核加成和环加成反应进行了研究,合成出了一系列新的2位取代的嘌呤衍生物.化合物的结构均经元素分析、1HNMR、13CNMR和MS确证.提出2-乙烯基-9-苄基嘌呤与苯硫酚的反应机理为氧化加成而非亲核加成,采用单晶X射线衍射法对主要产物的结构进行了确认.
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| 关 键 词： | 2-碘-嘌呤 2-乙烯基-嘌呤 Stille偶合反应 亲核加成反应 环加成反应 |
| 文章编号： | 0251-0790(2003)09-1592-07 |
| 收稿时间： | 2002-09-23 |
Studies on Synthesis of 2-Substituted-purine Derivatives |
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| LIU Fu-Sheng,YU Shi-Tao,GE Xiao-Ping,YANG Jin-Zong.Studies on Synthesis of 2-Substituted-purine Derivatives[J].Chemical Research In Chinese Universities,2003,24(9):1592-1598. |
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| Authors: | LIU Fu-Sheng YU Shi-Tao GE Xiao-Ping YANG Jin-Zong |
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| Institution: | 1. College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;
2. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China |
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| Abstract: | The Stille coupling reaction between 2-iodo-9-benzylpurine and RSnBu3 and the nucleophilic addition and cycloaddition of 2-vinyl-9-benzylpurine were studied. A series of new 2-substituted purined-erivatives were synthesized and characterized by elemental analysis, 1H NMR, 13C NMR and MS. It was demonstrated that the reaction mechanism between 2-vinyl-9-benzylpurine and benzenethiol was oxidative addition rather than nucleophilic addition. The structure of the main product was determined by single-crystal X-ray method. |
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| Keywords: | 2-Iodo-purine 2-Vinyl-purine Stille coupling Nucleophilic addition Cycloaddition |
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