Palladium-catalyzed regioselective arylation of imidazo[1,2-a]pyrimidine |
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| Authors: | Li Wenjie Nelson Dorian P Jensen Mark S Hoerrner R Scott Javadi Gary J Cai Dongwei Larsen Robert D |
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| Institution: | Process Research Department, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA. wenjie_li@merck.com |
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| Abstract: | Imidazo1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo1,2-a]pyrimidines from the unsubstituted heterocycle. reaction: see text] |
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