Kinetics of amide and peptide cleavage by alkaline hydrogen peroxide |
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Authors: | Gómez-Reyes Baldomero Yatsimirsky Anatoly K |
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Institution: | Facultad de Química, Universidad Nacional Autónoma de México, 04510 D.F., Mexico. |
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Abstract: | The hydroperoxide anion cleaves unactivated amides and peptides although it is completely unreactive toward ethyl esters. The cleavage by HO2(-) proceeds faster than by OH(-) and involves additional routes with general acid assistance by H2O2 and general base assistance by OH(-) and HO2(-). Cleavage of polypeptides occurs at the N-terminal peptide bond. reaction: see text] |
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