Cubic equation-of-state correlation of the solubility of some anti-inflammatory drugs in supercritical carbon dioxide |
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| Institution: | 1. Departamento de Engenharia Química, Universidade de Coimbra, Pólo II, Pinhal de Marrocos, 3030-290 Coimbra, Portugal;2. Instituto de Biologia Experimental e Tecnológica, Av. República, Apartado 12, 2780-901 Oeiras, Portugal;1. Luohe Medical College, Luohe, Henan 462000, China;2. The Third Affiliated Hospital of Luohe Medical College, Luohe, Henan 462000, China;3. Institute of Engineering and Technology, Department of Hydraulics and Hydraulic and Pneumatic Systems, South Ural State University, Lenin Prospect 76, Chelyabinsk 454080, Russian Federation;1. G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskaya Str. 1, 153045 Ivanovo, Russia;2. Tikhonov Moscow Institute of Electronics and Mathematics, School of Applied Mathematics, HSE University, 34, Tallinskaya Ulitsa, 123458 Moscow, Russia;3. Institut für Nichtklassische Chemie e.V., Permoserstr. 15, 04318 Leipzig, Germany;1. School of Chemical Science and Technology, Yunnan University, 650091, Yunan province, China;2. Department of Chemical Engineering and Petroleum Industries, Al-Mustaqbal University College, Babylon 51001, Iraq;3. Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow 119991, Russian Federation;4. Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow 109240, Russian Federation;5. Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia;6. Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt;7. Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India;8. Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan;9. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam;10. Department of Computer Science, Jeddah International College, Jeddah, Saudi Arabia;11. Mechanical and Materials Engineering Department, Faculty of Engineering, University of Jeddah, P.O. Box 80327, Jeddah 21589, Saudi Arabia;1. Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia;2. Depaertment of Pharmaceutical Chemistry, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia;3. Addiction and Neuroscience Research Unit, College of Pharmacy, Taif University, Al-Hawiah, Taif 21944, Saudi Arabia;4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia |
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| Abstract: | The accurate experimental determination of solid drug solubility in supercritical fluids (SCFs) and its correlation are crucially important to the development of supercritical technologies for the pharmaceutical industry. In this work, the solubilities of flurbiprofen, ketoprofen, naproxen and ibuprofen in supercritical carbon dioxide (scCO2) were correlated using the Peng–Robinson (PR), Soave–Redlich–Kwong (SRK) and Patel–Teja–Valderrama (PTV) equations-of-state with van der Waals (vdW), Panagiotopoulos–Reid (mrPR) and Mukhopadhyay–Rao (MR) mixing rules. Several modeling and correlation computational programs were developed in Mathematica®, a powerful symbolic computational language. Correlations were compared and discussed on the basis of the employed equation-of-state and mixing/combining rules. The importance of the estimation methods used for the determination of critical and other drug physical properties (namely drug's sublimation pressure) was also underlined in the discussion of the correlation results quality. A potential helpful procedure (based on simultaneous correlation of one of the critical or physicochemical properties) is suggested, in order to satisfactorily choose property estimation methods to use. |
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