Facile microwave-assisted synthesis of bis-pyrazol pyrimidine derivatives via an <Emphasis Type="Italic">N</Emphasis>-alkylation reaction |
| |
Authors: | Shi-Wen Huang Jin-Sheng Cheng Li Qian Suo-Yi Huang |
| |
Institution: | (1) Department of Chemistry, Youjiang Medical College for Nationalities, Baise, 533000, China;(2) Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China; |
| |
Abstract: | Abstract We present herein a new and efficient method for synthesis of bis-pyrazol pyrimidine derivatives by N-alkylation using a microwave-assisted synthetic process. Two new compounds, N-(4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)methyl nicotinonitrile and 2,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-4-methyl nicotinonitrile, were synthesized by the N-alkylation reaction. The novel compounds were characterized by Fourier transform infrared spectrometry, ultraviolet spectroscopy,
elemental analysis, and nuclear magnetic resonance spectroscopy, etc. The microwave-assisted procedures have noteworthy advantages
in terms of thermal efficiency over those carried out by conventional heating methods. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|