Stability studies on nifedipine tablets using thermogravimetry and differential scanning calorimetry |
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| Authors: | R. O. C. Filho P. I. B. M. Franco E. C. Conceição M. I. G. Leles |
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| Affiliation: | 1.LAMES-Laboratório de Métodos de Extra??o e Separa??o, Instituto de Química,Univ. Federal de Goiás-UFG Campus Samambaia,Goiania-GO,Brasil;2.Faculdade de Farmácia,Univ. Federal de Goiás-UFG,Goiania-GO,Brazil |
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| Abstract: | A formulation of nifedipine tablets was prepared in the present research. The tablets were conditioned in amber-colored glass containers and placed in a climatized room at 40°C and relative humidity of 75% for 180 days. Differential scanning calorimetry (DSC) and thermogravimetry (TG) were used in order to evaluate the thermal properties of nifedipine, the excipients and two well-known nifedipine degradation products. The results demonstrated that there is no evidence on the interaction between nifedipine and excipients, or degradation products. |
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| Keywords: | differential scanning calorimetry (DSC) nifedipine stability studies thermogravimetry (TG) |
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