Unambiguous identification of superparamagnetic iron oxide particles through quantitative susceptibility mapping of the nonlinear response to magnetic fields |
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Authors: | Tian Liu Pascal SpincemailleLudovic de Rochefort Richard WongMartin Prince Yi Wang |
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Affiliation: | Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Department of Radiology, Weill Cornell Medical College, New York, NY 10022, USA |
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Abstract: | Superparamagnetic iron oxide (SPIO) particles generate signal void regions on gradient echo images due to their strong magnetization. In practice, the signal void region might be indistinguishable from that generated by air. However, the response of SPIO to an externally applied magnetic field is nonlinear. Magnetization of SPIO saturates at around 1 T while magnetization of water and air increase linearly with field strength. Phantom experiment and mice experiments demonstrated the feasibility of a nonambiguous identification of superparamagnetic contrast agents. |
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Keywords: | MRI SPIO Air Nonlinear magnetization response Quantitative susceptibility mapping COSMOS |
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