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N-Acetyl peak in MR spectra of intracranial metastatic mucinous adenocarcinomas
Authors:Xiang Liu  Barbara I Germin  Jianhui Zhong  Sven Ekholm
Institution:1. Department of Imaging Sciences, University of Rochester School of Medicine and Dentistry, PO Box 648, Rochester, NY 14642, USA;2. Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Abstract:Absence of N-acetylaspartate (NAA) is one important diagnostic criterion of MR spectroscopy (MRS) that may suggest that an intracranial mass lesion is a metastasis. We report two cases of histopathology-confirmed intracranial metastatic mucinous adenocarcinoma, which predominantly showed a large metabolite peak at 2.0 ppm, mimicking an NAA peak of normal brain tissue. This finding could be of help in the interpretation of MRS in cases of intracranial enhancing mass lesions, metastases or gliomas.
Keywords:Metastatic mucinous adenocarcinoma  MR spectroscopy  N-Acetylaspartate  Glycoprotein
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