Quantitative evaluation of optimal imaging parameters for single-cell detection in MRI using simulation |
| |
Authors: | Ali-Reza Mohammadi-Nejad Gholam-Ali Hossein-Zadeh Hamid Soltanian-Zadeh |
| |
Institution: | 1. Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran;2. Signal and Image Processing Group, School of Cognitive Sciences, Institute for Studies in Theoretical Physics and Mathematics (IPM), Tehran, Iran;3. Department of Radiology, Medical Image Analysis Laboratory, Henry Ford Hospital, Detroit, MI, USA |
| |
Abstract: | Super-paramagnetic iron oxide (SPIO) nanoparticles are actively investigated to enhance disease detection through molecular imaging using magnetic resonance imaging (MRI). Detection of the cells labeled by SPIO depends on the MRI protocols and pulse sequence parameters that can be optimized. To evaluate the sensitivity and specificity of the image acquisition methods and to obtain optimal imaging parameters for single-cell detection, we further developed an MRI simulator. The simulator models an object (tissue) at a microscopic level to evaluate effects of spatial distribution and concentration of nanoparticles on the resulting image. In this study, the simulator was used to evaluate and compare imaging of the labeled cells by the gradient-echo (GE), true-FISP fast imaging employing steady-state acquisition (FIESTA)] and echo-planar imaging (EPI) pulse sequences. Effects of the imaging and object parameters, such as field strength, imaging protocol and pulse sequence parameters, imaging resolution, cell iron load, position of SPIO within the voxel and cell division within the voxel, were investigated in the work. The results suggest that true-FISP has the highest sensitivity for single-cell detection by MRI. |
| |
Keywords: | Molecular imaging Magnetic resonance imaging (MRI) Simulator Super-paramagnetic iron-oxide (SPIO) nanoparticles Optimal pulse sequence parameters Single-cell detection |
本文献已被 ScienceDirect 等数据库收录! |
|