Potent algicides based on the cyanobacterial alkaloid nostocarboline |
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Authors: | Blom Judith F Brütsch Tobias Barbaras Damien Bethuel Yann Locher Hans H Hubschwerlen Christian Gademann Karl |
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Affiliation: | Institute of Plant Biology, University of Zürich, Seestr. 187, CH-8802 Kilchberg. |
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Abstract: | [structure: see text] Nostocarboline and seven derivatives were prepared and displayed minimal inhibitory concentration (MIC) values >or=100 nM against the growth of Microcystis aeruginosa PCC 7806, Synechococcus PCC 6911, and Kirchneriella contorta SAG 11.81, probably via the inhibition of photosynthesis. The natural product hybrid nostocarboline/ciprofloxacin displayed additional antibacterial activity against several Gram-negative bacteria (MICs >or=0.7 microM). Nostocarboline can thus be considered a potent, selective, readily available, natural algicide. |
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