Unusual highly regioselective direct aldol additions with a moisture-resistant and highly efficient titanium catalyst |
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| Authors: | Mahrwald Rainer Schetter Bernd |
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| Institution: | Humboldt-Universit?t zu Berlin, Institut für Chemie, Germany. rainer.mahrwald@rz.hu-berlin.de |
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| Abstract: | reaction: see text] The extremely robust and water-stable tetranuclear complex Ti(4)(mu-BINOLato)(6)(mu(3)-OH)(4) was found to catalyze the direct aldol addition with high regioselectivities at the more steric alpha-encumbered side of unsymmetrical ketones. As few as 0.2 mol % loadings with this cluster were enough to afford complete conversions. The reaction proceeds very smoothly without a significant amount of byproducts. The formation of quaternary stereocenters is described. |
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