An atom-economic synthesis of nitrogen heterocycles from alkynes |
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Authors: | Trost Barry M Lumb Jean-Philip Azzarelli Joseph M |
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Affiliation: | Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States. bmtrost@stanford.edu |
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Abstract: | A robust route to 2,4-disubstituted pyrrole heterocycles relying upon a cascade reaction is reported. The reaction benefits from operational simplicity: it is air and moisture tolerant and is performed at ambient temperature. Control over the reaction conditions provides ready access to isopyrroles, 2,3,4-trisubstituted pyrroles, and 3-substituted pyrollidin-2-ones. |
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