Assessment of role of rosmarinic acid in preventing oxidative process of low density lipoproteins |
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| Authors: | Andreia Tache Gabriel-Lucian Radu Simona-Carmen Litescu |
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| Affiliation: | 1. National Institute of Research and Development for Biological Science, 296 Splaiul Independentei, 060031, Bucharest, Romania
2. Politehnica University of Bucharest, Faculty of Applied Chemistry and Materials Science, 1-7 Polizu, 0101061, Bucharest, Romania
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| Abstract: | This study aimed to assess the antioxidant compound effects on oxidisable substrates, using an effective bio-mimetic system based on human low density lipoproteins (LDL). Thermally generated radicals induce LDL oxidative changes to be identified and quantified. The bio-mimetic system thus developed responded linearly to radicals?? concentration over a range of 10?6-10?5 mol L?1. Cu2+ accentuates lipoperoxidation but, when rosmarinic acid was present, Cu2+ produced an unexpected effect, i.e. increased antioxidant efficiency against lipoperoxidation. Rosmarinic acid inhibits production of lipoperoxides by up to 30 % in the absence of Cu2+ and up to 70 % in its presence when the rosmarinic acid-to-Cu molar ratio is 1: 1. |
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