| 两个苯甲羟肟酸有机锡配合物的合成、结构及抗癌活性 |
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| 引用本文： | 邓欣,张复兴,卿菁菁,杨舸,何帆,何丽芳,刘智辉,侯帅鹏. 两个苯甲羟肟酸有机锡配合物的合成、结构及抗癌活性[J]. 无机化学学报, 2013, 29(18) |
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| 作者姓名： | 邓欣 张复兴 卿菁菁 杨舸 何帆 何丽芳 刘智辉 侯帅鹏 |
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| 作者单位： | 衡阳师范学院化学与材料科学学院, 功能金属有机化合物湖南省重点实验室, 金属有机新材料湖南省普通高等学校重点实验室, 湘江上游重金属污染监测与治理湖南省工程研究中心, 衡阳 421008 |
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| 基金项目： | 湖南省自然科学青年基金(No.2021JJ40010)、湖南省功能金属有机化合物重点实验室开放基金(No.2021HSKFJJ002)、湖南省应用特色学科基金、湖南省高校科技创新团队支持计划和国家、湖南省和学校大学生创新创业训练计划项目资助。 |
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| 摘 要： | 合成了2个苯甲羟肟酸有机锡配合物：[(o-Cl-C6H4CH2)2Sn (C6H5CONO)2](1)和[(o-CH3-C6H4CH2)2Sn (C6H5CONO)(C6H5COO)](2)。通过元素分析、红外光谱、核磁共振氢谱、热重分析、单晶X射线衍射等方法对配合物进行了结构表征，对其结构进行量子化学从头计算和体外抗癌活性研究。结果显示：配合物均为单锡核结构，配合物1为六配位的畸变八面体构型，配合物2为五配位的畸变三角双锥构型；配合物1对人宫颈癌细胞(HeLa)、肝癌细胞(HuH-7)和肺腺癌细胞(H1975)显示出比临床使用的顺铂强的抑制活性，而配合物2的抑制活性要弱得多。
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| 关 键 词： | 二(邻氯苄基)锡二(苯甲羟肟酸)配合物 二(邻甲基苄基)锡苯甲羟肟酸苯甲酸混配物 晶体结构 量子化学 体外抗肿瘤活性 |
| 收稿时间： | 2023-05-23 |
| 修稿时间： | 2023-09-27 |
Synthesis, structure, and anticancer activity of two benzohydroxamic acid organotin complexes |
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| DENG Xin,ZHANG Fu-Xing,QING Jing-Jing,YANG Ge,HE Fan,HE Li-Fang,LIU Zhi-Hui,HOU Shuai-Peng. Synthesis, structure, and anticancer activity of two benzohydroxamic acid organotin complexes[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(18) |
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| Authors: | DENG Xin ZHANG Fu-Xing QING Jing-Jing YANG Ge HE Fan HE Li-Fang LIU Zhi-Hui HOU Shuai-Peng |
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| Affiliation: | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China |
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| Abstract: | Two benzohydroxamic acid organotin complexes [(o-Cl-C6H4CH2)2Sn(C6H5CONO)2] (1) and [(o-CH3-C6H4CH2)2Sn(C6H5CONO) (C6H5COO)] (2) were synthesized by solvothermal method using methanol as a solvent. Complexes 1 and 2 were characterized by elemental analysis, IR, 1H NMR, thermogravimetric analysis, single-crystal X-ray diffraction, etc. The study on the complexes has been performed with quantum chemistry calculation and in vitro anticancer activity. The results show that the two complexes are monotin nuclear structures; complexes 1 and 2 are the six-coordinated distorted octahedron configuration and seven-coordinated distorted triangular bipyramid configuration, respectively. Complex 1 showed stronger inhibitory activity on human cervical cancer cells (HeLa), hepatoma cells (HuH-7), and lung adenocarcinoma cells (H1975) than cisplatin, while complex 2 showed much weaker inhibitory activity. |
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| Keywords: | bis(o-chlorobenzyl)tin bis(benzohydroxamic acid) complex bis(o-methylbenzyl)tin benzohydroxamic acid and benzoic acid mixed-ligand complex crystal structure quantum chemistry in vitro antitumor activity |
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