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A Fast and Simple Screening Method for m-Nisoldipine and Its Related Substances by MEKC |
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| Authors: | Kong De-Zhi Yuan Zhi-Fang Zhang Xiao-Wei Sheng Xiao-Na Wang Na Xing Song-song Du Yu-Min Zhang Lan-Tong |
| Institution: | 1.Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, China ;2.Department of Metabolic Regulation, Institute of Aging and Adaptation, Shinshu University Graduate School of Medicine, Nagano, Japan ;3.Department of Pharmaceutical Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, China ; |
| Abstract: | A rapid and simple method has been developed and validated for the determination of m-nisoldipine and its five related substances using micellar electrokinetic capillary chromatography (MEKC). The key factors, including pH, buffer concentration and buffer additive, sodium dodecyl sulfate (SDS) concentration, applied voltage and temperature were systematically investigated in an uncoated fused silica capillary. The total analysis time was less than 9 min. The forced degradation products of m-nisoldipine, which were induced by hydrogen peroxide, acidic and basic conditions, heat and light, were also tested. |
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