Missing-Linker-Confined Single-Atomic Pt Nanozymes for Enzymatic Theranostics of Tumor |
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| Authors: | Prof Dongdong Wang Prof Lei Zhang Dr Changlai Wang Zhiyu Cheng Wei Zheng Dr Pengping Xu Prof Qianwang Chen Prof Yanli Zhao |
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| Institution: | 1. Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026 P. R. China;2. Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, 230026 P. R. China;3. School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, 637371 Singapore |
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| Abstract: | Conventional nanozymes often possess low active site density. Pursuing effective strategies for constructing highly active single-atomic nanosystems with maximum atom utilization efficiency is exceptionally attractive. Herein, we develop a facile “missing-linker-confined coordination” strategy to fabricate two self-assembled nanozymes, i.e., conventional nanozyme (NE) and single-atomic nanozyme (SAE), which respectively consist of Pt nanoparticles and single Pt atoms as active catalytic sites anchored in metal–organic frameworks (MOFs) with encapsulated photosensitizers for catalase-mimicking enhanced photodynamic therapy. Compared to a Pt nanoparticle-based conventional nanozyme, a Pt single-atomic nanozyme shows enhanced catalase-mimicking activity in generating oxygen for overcoming tumor hypoxia, thus exhibiting a more efficient reactive oxygen species generation and high tumor inhibition rate. |
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| Keywords: | Cancer Therapy Metal–Organic Frameworks Missing Linker Nanozymes Self-Assembly |
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