Highly enantioselective phenylacetylene additions to ketones catalyzed by (S)-BINOL-Ti complex |
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Authors: | Zhou Yifeng Wang Rui Xu Zhaoqing Yan Wenjin Liu Lei Kang Yongfeng Han Zhijian |
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Affiliation: | Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China. |
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Abstract: | The readily available and inexpensive (S)-BINOL ligand in combination with Ti(O(i)Pr)(4) is an effective chiral catalyst for the catalytic asymmetric addition of alkynylzinc to unactivated simple ketones. Good to excellent enantioselectivities were achieved. No previous case has been reported successfully using BINOL to catalyze the addition of phenylacetylene to unactivated ketones, and thus the utility of BINOL in asymmetric catalysis is expanded. |
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