Dual‐responsive supramolecular self‐assembly of inclusion complex of an azobenzene‐ended poly(ε‐caprolactone) with a water‐soluble pillar[6]arene and its application in controlled drug release |
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| Authors: | Zaizai Tong Junyi Zhou Runsheng Huang Jie Zhou Runke Zhang Wangqian Zhuo Guohua Jiang |
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| Affiliation: | Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Department of Materials Science and Engineering, Zhejiang Sci‐Tech University, Hangzhou, China |
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| Abstract: | Dual photo‐ and pH‐responsive polymeric vesicles are constructed from a host–guest complex between a water‐soluble pillar[6]arene and an azobenzene ended functionalized poly(ε‐caprolactone). Reversible morphological transitions between vesicles and solid aggregates are achieved upon repeated UV stimulus and pH stimulus. Moreover, the polymeric vesicles present excellent cytocompatibility toward HepG2 cells and can be further applied for controlled release of a hydrophilic model drug, DOX?HCl. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55 , 2477–2482 |
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| Keywords: | drug delivery systems host– guest systems stimuli‐sensitive polymers |
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