Synthesis and conjugation of a triiodohydroxylamine for the preparation of highly X‐ray opaque poly(ε‐caprolactone) materials |
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| Authors: | Brooke A. Van Horn Lundy L. Davis Samantha E. Nicolau Emma E. Burry Victoria O. Bailey Fernanda D. Guerra Frank Alexis Daniel C. Whitehead |
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| Affiliation: | 1. Department of Chemistry and Biochemistry, College of Charleston, Charleston, South Carolina;2. Department of Bioengineering, Clemson University, 203 Rhodes Research Center Annex, Clemson, South Carolina;3. Department of Bioengineering, Institute of Biological Interfaces of Engineering, Clemson University, Clemson, South Carolina;4. Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, South Carolina |
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| Abstract: | To address a need for highly X‐ray opaque biodegradable materials, a series of poly(ε‐caprolactone) derivatives were prepared using oxime post‐polymerization modification to conjugate two different iodinated hydroxylamines. These materials were synthesized with up to 32 wt. % iodine content and demonstrated improved X‐ray contrast relative to both the ketone precursors and previously reported monoiodinated materials. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55, 787–793 |
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| Keywords: | conjugation iodine oxime polycaprolactone X‐ray |
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