A study on 4-acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones |
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Authors: | Alkan Muzaffer Yüksek Haydar Islamo?lu Fatih Bahçeci Sule Calapo?lu Mustafa Elmasta? Mahfuz Ak?it Hüseyin Ozdemir Mustafa |
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Institution: | Education Faculty, Kafkas University, 36100 Kars, Turkey. |
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Abstract: | Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, 1HNMR, 13C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pKa values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(pmethoxybenzoylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities. |
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