Two-dimensional model of vesicle adhesion on curved substrates |
| |
Authors: | Wendong Shi Xi Qiao Feng Huajian Gao |
| |
Affiliation: | (1) Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China;(2) Division of Engineering, Brown University, 182 Hope Street, Providence, RI 02912, USA |
| |
Abstract: | We develop a two dimensional model of a vesicle adhered on a curved substrate via long-range molecular interactions while subjected to a detachment force. The relationship between the force and displacement of the vesicle is investigated as a function of the substrate shape. It is shown that both the force– displacement relationship and the maximum force at pull-off are significantly dependent on the substrate shape. The results suggest that probes with different tip shapes may be designed for cell manipulation. For example, we demonstrate that a vesicle can be pulled off a flat surface using a probe with a curved tip.The project supported by the National Natural Science Foundation of China (10525210 and 10121202) and the 973 Program. |
| |
Keywords: | Biomechanics Cell adhesion Vesicle Adhesive contact Cell manipulation |
本文献已被 维普 万方数据 SpringerLink 等数据库收录! |
|