Copper sulfate-pentahydrate-1,10-phenanthroline catalyzed amidations of alkynyl bromides. Synthesis of heteroaromatic amine substituted ynamides |
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| Authors: | Zhang Yanshi Hsung Richard P Tracey Michael R Kurtz Kimberly C M Vera Eymi L |
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| Institution: | Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. |
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| Abstract: | A practical cross-coupling of amides with alkynyl bromides using catalytic CuSO(4).5H(2)O and 1,10-phenanthroline is described here. This catalytic protocol is more environmentally friendly than the use of CuCN or copper halides and provides a general entry for syntheses of ynamides including various new sulfonyl and heteroaromatic amine substituted ynamides. Given the interest in ynamides, this N-alkynylation of amides should be significant for the future of ynamides in organic synthesis. |
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