摘 要: | HydrolysispePhdesatapboCularbondisvery~rtanincheIinStryandphannacology.Concehongonthestudyofcatalghcantithaes,althoughmpsuccessfiileXaInleshavbeenreportedinestershydrol}sis-therearestillgrcaanculhesinaInidehydrol}sis.CarboothaseA(CPA)isaproteinofbothesteraseandPephdaseachvihes,soweselectedthesubStratehippUrylphenylalamneofCPAasmodeltodesignandSynthesizenewhaPtenmoleculewhichcontalns-SOzNH-groupinsteadofco2NH-b}'bioisostericreplacement,andexPeCtedtopreParecatalyticantibodwithpePhdase…
|