Anticancer effect of three pyrazole derivatives |
| |
Authors: | Bouabdallah Ibrahim M'Barek Lahcen Ait Zyad Abdelmajid Ramdani Abdelkrim Zidane Ismail Melhaoui Ahmed |
| |
Institution: | Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Sciences, University Mohammed Ier, BP 524, 60 000 Oujda, Morocco. |
| |
Abstract: | The evaluation of the cytotoxic properties in vitro of three synthetic tripods containing pyrazole: N,N-bis(3,5-dimethylpyrazol-1-yl)methyl]aniline (1); N,N-tetrakis(3,5-dimethylpyrazol-1-yl)methyl]-para-phenylenediamine (2); and N,N-tetrakis-(1,5-dimethylpyrazol-3-yl)methyl]-para-phenylenediamine (3), was examined for their cytotoxic activity on two tumor cell lines: P815 (murin mastocytoma) and Hep (human laryngeal carcinome). While the compound 2 shows a small cytotoxic activity, compounds 1 and 3 are more cytotoxic against both cell lines. However, this cytotoxicity is more pronounced against Hep cell line (IC50: 3.25 microg mL(-1) for compound 1 and 6.92 microg mL(-1) for compound 3) than P815 cell line (IC50: 17.82 microg mL(-1) for compound 1 and 37.21 microg mL(-1) for compound 3). Statistical analysis shows that the compound 1 is two- to threefold more cytotoxic than compound 3 (P < 0.05). Interestingly, the cytotoxicity induced by compound 1 against Hep cell line is more important than that induced by adriamycin used as a positive control. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|