The thermal and photostability of solid pharmaceuticals |
| |
Authors: | Glass B. D. Novák Cs. Brown M. E. |
| |
Affiliation: | (1) School of Pharmacy, James Cook University Townsville, Queensland, 4811, Australia;(2) Hungarian Academy of Sciences, Budapest University of Techology and Economics, Research Group of Technical Analytical Chemistry H-1111 Budapest, Szt. Gellért tér 4, Hungary;(3) Chemistry Department, Rhodes University Grahamstown, 06140, South Africa E-mail |
| |
Abstract: | Drugs degrade to different extents on separate exposure to heat, moisture, oxidation and light. Combination of these stresses causes very complex behaviour. Many studies have been reported of the thermal behaviour of drugs in the solid-state, but most of the information available on the photodegradation of drugs refers to reactions in solution, (usually aqueous) and photoreactions in the solid-state are even more complex. In drug formulations, the presence of excipients adds further complications because the excipients may increase, have no effect on, or decrease the inherent stabilities of the drug. The literature has been explored to review the thermal and photostabilities of solid pharmaceuticals. This revised version was published online in August 2006 with corrections to the Cover Date. |
| |
Keywords: | thermal analysis kinetic analysis thermal stability drugs pharmaceuticals photostability |
本文献已被 SpringerLink 等数据库收录! |
|