| 艾托拉嗪的合成 |
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| 引用本文： | 李春明,林原斌,张耕,林彦飞. 艾托拉嗪的合成[J]. 化学研究与应用, 2009, 21(3) |
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| 作者姓名： | 李春明 林原斌 张耕 林彦飞 |
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| 作者单位： | 湘潭大学化学学院,环境友好化学与应用省部共建教育部重点实验室,湖南,湘潭,411105;湘潭大学化学学院,环境友好化学与应用省部共建教育部重点实验室,湖南,湘潭,411105;湘潭大学化学学院,环境友好化学与应用省部共建教育部重点实验室,湖南,湘潭,411105;湘潭大学化学学院,环境友好化学与应用省部共建教育部重点实验室,湖南,湘潭,411105 |
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| 摘 要： | 自从色洛托宁(Serotonin)在1948年作为神经传导素被发现以后,它就与中枢神经系统(CNS)的活动联系在一起.经过科学家们的多年努力,芳基哌嗪作为种类繁多的5-HT1A受体中的一类得到了迅速发展,像布斯哌隆(Buspirone)和伊沙匹隆((Ipsapirone)很早就作为有效的抗焦虑和抗抑郁症药物得到广泛的应用.
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| 关 键 词： | 3-硝基邻苯二酚 艾托拉嗪 合成 |
The synthesis of eltoprazine |
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| LI Chun-ming,LIN Yuan-bin,ZHANG Gen,LIN Yan-fei. The synthesis of eltoprazine[J]. Chemical Research and Application, 2009, 21(3) |
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| Authors: | LI Chun-ming LIN Yuan-bin ZHANG Gen LIN Yan-fei |
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| Affiliation: | Key Laboratory of Environment Friendly Chemistry and Application of Ministry of Education;Department of Chemistry;Xiangtan University;Xiangtan 411105;China |
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| Abstract: | A new method for synthesizing eltoprazine is presented in this article.3-nitrobenzene-1,2-diol is synthesized with pyrocatechol via a nitrating reaction,and then we use 1,2-dibromoethane as the cycling agent to prepare 5-nitro-2,3-dihydrobenzo[b]dioxine.5-amino-2,3-dihydrobenzo[b]dioxine is synthesized with 5-nitro-2,3-dihydrobenzo[b]dioxine via a reductive reaction in ethanol using hydrazine hydrate as reductive agent and Pd/C as catalyst.The object product eltoprazine is then prepared by a cycling reactio... |
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| Keywords: | 3-nitrocatechol eltoprazine synthesis |
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