One-pot, multicomponent route to pyrazoloquinolizinones |
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| Authors: | Chebanov Valentin A Saraev Vyacheslav E Desenko Sergey M Chernenko Vitaliy N Shishkina Svetlana V Shishkin Oleg V Kobzar Kiril M Kappe C Oliver |
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| Institution: | State Scientific Institution "Institute for Single Crystals" of the National Academy of Sciences of Ukraine, Lenin Ave, Kharkiv, Ukraine. |
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| Abstract: | reaction: see text] An efficient synthesis of 5a-hydroxy-4,5,5a,6,7,8-hexahydropyrazolo4,3-c]quinolizin-9-ones based on the three-component condensation of 5-aminopyrazoles, aromatic aldehydes, and cyclic 1,3-diketones is described. The multicomponent reaction is performed under strongly basic conditions applying controlled microwave heating in a sealed vessel and involves an unusual base-mediated ring-opening/recyclization of the cyclic 1,3-diketone moiety. |
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