Mixed-phase synthesis of glycopeptides using a N-peptidyl-2,4-dinitrobenzenesulfonamide-thioacid ligation strategy |
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| Authors: | Karmakar Partha Talan Rommel S Sucheck Steven J |
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| Affiliation: | Department of Chemistry, The University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, USA. |
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| Abstract: | A strategy for the solid phase peptide synthesis (SPPS) and coupling of N-peptidyl and N-glycopeptidyl 2,4-dinitrobenzenesulfonamides (dNBS) with C-terminal peptidyl thioacids has been developed. The resulting N-dDNBS peptides were coupled to generate longer peptides. Ligation reactions were complete within 15 to 20 min. |
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