Stereoselective synthesis of alpha-monofluorinated phosphonate mimetics of naturally occurring phosphoserine and phosphothreonine,via electrophilic fluorination of lithiated bis-lactim ethers |
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| Authors: | Ruiz María Ojea Vicente Quintela José M Guillín Juan J |
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| Institution: | Departamento de Química Fundamental, Universidade da Coru?a, Campus da Zapateira, s/n, 15071 A Coru?a, Spain. ruizpr@udc.es |
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| Abstract: | Electrophilic fluorinations of lithiated bis-lactim ethers derived from cyclo-L-AP4-D-Val] allow a direct access to alpha-monofluorinated phosphonate mimetics of naturally occurring phosphoserine and phosphothreonine, in enantiomerically pure form and suitably protected for solid-phase peptide synthesis. |
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