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Recent advances in the preparation and application of monolithic capillary columns in separation science
Authors:Tingting Hong  Xi Yang  Yujing Xu  Yibing Ji
Institution:1. Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China;2. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Nanjing, 210009, China
Abstract:Novel column technologies involving various materials and efficient reactions have been investigated for the fabrication of monolithic capillary columns in the field of analytical chemistry. In addition to the development of these miniaturized systems, a variety of microscale separation applications have achieved noteworthy results, providing a stepping stone for new types of chromatographic columns with improved efficiency and selectivity. Three novel strategies for the preparation of capillary monoliths, including ionic liquid-based approaches, nanoparticle-based approaches and “click chemistry”, are highlighted in this review. Furthermore, we present the employment of state-of-the-art capillary monolithic stationary phases for enantioseparation, solid-phase microextraction, mixed-mode separation and immobilized enzyme reactors. The review concludes with recommendations for future studies and improvements in this field of research.
Keywords:Capillary monolith  Click chemistry  Complex sample  Enantioseparation  Ionic liquid  Nanoparticle
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