|
|||||
|
|
Colorimetric detection of sodium ion in serum based on the G-quadruplex conformation related DNAzyme activity |
|
| Authors: | Hongxia Sun Hongbo Chen Xiufeng Zhang Yan Liu Aijiao Guan Qian Li Qianfan Yang Yunhua Shi Shujuan Xu Yalin Tang |
| Institution: | 1. National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China;2. College of Chemistry Engineering, North China University of Science and Technology, Tangshan, 063009, China;3. Graduate University of the Chinese Academy of Sciences, Yuquan Road 19(A), Shijingshan District, Beijing 100049, PR China |
| Abstract: | There has been a big challenge in developing the Na+ sensor that can be practically used in the physiological system with the interference of large amounts of K+. In this research, a novel Na+ sensor has been designed based on the G-quadruplex-conformation related DNAzyme activity. The sensor exhibits high selectivity and sensitivity with the detection limit of 0.6 μM, which enables the sensor to be practically used in determination of the Na+ level in serum. The research not only provides a simple Na+ sensor but also opens a new way for developing the detection technology of Na+. |
| Keywords: | G-quadruplex DNAzyme Na+ detection Colorimetric Serum |
| 本文献已被 ScienceDirect 等数据库收录！ | |