Palladium-catalyzed asymmetric synthesis of axially chiral molecules
Authors:
J. C. Fiaud and J. Y. Legros
Affiliation:
Laboratoire de Synthèse Asymétrique, Université Paris-Sud, Bât. 420, 91405 Orsay Cedex France
Abstract:
The asymmetric synthesis of chiral 3-alkylidene bicyclo[3.3.0]octane and 4-substituted 1-alkylidene cyclohexane systems has been carried out (in up to 40% ee) by the palladium-catalyzed reaction of allylic acetates with sodium dimethyl malonate or morpholine.