Use of cyclopropanols as conformational constraints in RCM |
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Authors: | Lysenko Ivan L Lee Hyung Goo Cha Jin Kun |
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Institution: | Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA. |
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Abstract: | reaction: see text] Sequential application of the Kulinkovich cyclopropanation of carboxylic esters and RCM of the resulting cis-dialkenyl-tethered cyclopropanols provides an expedient route to functionalized medium-sized carbocycles. Subsequent elaboration of the cyclopropanol functionality, such as one-carbon ring expansion, to afford synthetically useful alpha,beta-enones is also worth noting. |
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