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Use of cyclopropanols as conformational constraints in RCM
Authors:Lysenko Ivan L  Lee Hyung Goo  Cha Jin Kun
Institution:Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
Abstract:reaction: see text] Sequential application of the Kulinkovich cyclopropanation of carboxylic esters and RCM of the resulting cis-dialkenyl-tethered cyclopropanols provides an expedient route to functionalized medium-sized carbocycles. Subsequent elaboration of the cyclopropanol functionality, such as one-carbon ring expansion, to afford synthetically useful alpha,beta-enones is also worth noting.
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