Switching the reactivity of dihydrothiopyran-4-one with aldehydes by aqueous organocatalysis: Baylis-Hillman, aldol, or aldol condensation reactions |
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Authors: | Abaee M Saeed Mojtahedi Mohammad M Pasha Ghasem F Akbarzadeh Elahe Shockravi Abbas Mesbah A Wahid Massa Werner |
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Institution: | Department of Organic Chemistry, Chemistry & Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran. abaee@ccerci.ac.ir |
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Abstract: | An aqueous medium containing catalytic amounts of a tertiary amine was employed to direct the chemoselectivity of the reaction of aldehydes with 1a. With DBU, 2 was formed at room temperature as a rare exemplary of Baylis-Hillman reactions in heterocyclic enones. DABCO alternated the pathway toward an aldol reaction to form syn/anti mixtures of 3 with the syn isomers being the major products. With Et(3)N, aldol condensation dominated. |
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