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Metal-amyloid-β peptide interactions: a preliminary investigation of molecular mechanisms for Alzheimer's disease
作者单位:JIAO Yong(Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China) ; YANG Pin(Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China) ;
基金项目:Supported by the National Natural Science Foundation of China (Grant Nos. 30470408 and 20637010) and the Youth Foundation of Science and Technology of Shanxi Province (Grant No. 2006021009)
摘    要:Although humans have spent exactly 100 years combating Alzheimer's disease (AD), the molecular mechanisms of AD remain unclear. Owing to the rapid growth of the oldest age groups of the population and the continuous increase of the incidence of AD, it has become one of the crucial problems to modern sciences. It would be impossible to prevent or reverse AD at the root without elucidating its molecular mechanisms. From the point of view of metal-amyloid-β peptide (Aβ) interactions, we review the molecular mechanisms of AD, mainly including Cu2 and Zn2 inducing the aggregation of Aβ, catalysing the production of active oxygen species from Aβ, as well as interacting with the ion-channel-like structures of Aβ. Moreover, the development of therapeutic drugs on the basis of metal-Aβ interactions is also briefly introduced. With the increasingly rapid progress of the molecular mechanisms of AD, we are now entering a new dawn that promises the delivery of revolutionary developments for the control of dementias.

关 键 词:Alzheimer's  disease  (AD)    amyloid-β  peptide    Cu2      Zn2      molecular  mechanisms    aggregation    active  oxygen  species    ion  channel
收稿时间:18 September 2006
修稿时间:24 November 2006

Metal-amyloid-β peptide interactions: a preliminary investigation of molecular mechanisms for Alzheimer’s disease
Authors:Jiao Yong  Yang Pin
Institution:(1) Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, China
Abstract:Although humans have spent exactly 100 years combating Alzheimer’s disease (AD), the molecular mechanisms of AD remain unclear. Owing to the rapid growth of the oldest age groups of the population and the continuous increase of the incidence of AD, it has become one of the crucial problems to modern sciences. It would be impossible to prevent or reverse AD at the root without elucidating its molecular mechanisms. From the point of view of metal-amyloid-β peptide (Aβ) interactions, we review the molecular mechanisms of AD, mainly including Cu2+ and Zn2+ inducing the aggregation of Aβ, catalysing the production of active oxygen species from Aβ, as well as interacting with the ion-channel-like structures of Aβ. Moreover, the development of therapeutic drugs on the basis of metal-Aβ interactions is also briefly introduced. With the increasingly rapid progress of the molecular mechanisms of AD, we are now entering a new dawn that promises the delivery of revolutionary developments for the control of dementias. Supported by the National Natural Science Foundation of China (Grant Nos. 30470408 and 20637010) and the Youth Foundation of Science and Technology of Shanxi Province (Grant No. 2006021009)
Keywords:Alzheimer’  s disease (AD)  amyloid-β  peptide  Cu2+            Zn2+            molecular mechanisms  aggregation  active oxygen species  ion channel
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