| 核苷二磷酸糖的合成研究进展 |
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| 引用本文： | 熊智毅,李俊霞,张殊佳.核苷二磷酸糖的合成研究进展[J].化学通报,2012(1):37-45. |
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| 作者姓名： | 熊智毅 李俊霞 张殊佳 |
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| 作者单位： | 大连大学环境与化学工程学院辽宁省生物有机化学重点实验室 |
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| 基金项目： | 国家自然科学基金项目(30873143)资助 |
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| 摘 要： | 核苷二磷酸糖在结构上是由1分子的糖或糖的衍生物和1分子的核苷二磷酸所组成,它是糖基转移酶的供体底物之一。糖基转移酶正被越来越多的应用于制备寡糖、糖缀合物和含糖基天然产物,因此研究核苷二磷酸糖的有效合成方法是很有必要的。本文总结了合成核苷二磷酸糖的各种化学法和酶法。
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| 关 键 词： | 核苷二磷酸糖 糖基转移酶 化学法 酶法 |
Progress on Synthesis of NDP-Sugars |
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| Xiong Zhiyi,Li Junxia,Zhang Shujia.Progress on Synthesis of NDP-Sugars[J].Chemistry,2012(1):37-45. |
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| Authors: | Xiong Zhiyi Li Junxia Zhang Shujia |
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| Institution: | (College of Environmental and Chemical Engineering,Key Laboratoryof Bioorganic Chemistry of Liaoning Province,Dalian University,Dalian 116622) |
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| Abstract: | NDP-sugars are composed of one sugar or sugar,s derivative molecule and one nucleoside diphosphate molecule in their structures;it is one of the substrates of glycosyltransferases which are the key enzymes to catalyze the synthesis of oligosaccharides,glycoconjugates and glycosylated natural products.Therefore,the studies of the efficient synthetic methods of NDP-sugars are very important.In this paper,both chemical and enzymatic strategies for the synthesis of NDP-sugars were summarized. |
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| Keywords: | NDP-sugars Glycosyltransferases Chemical strategies Enzymatic strategies |
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