Diversity‐Oriented Approach for Chemical Biology |
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| Authors: | Jun‐Seok Lee Jae Wook Lee Namyoung Kang Hyung‐Ho Ha Young‐Tae Chang |
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| Institution: | 1. Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;2. Department of Biological Chemistry, University of Science and Technology (UST), Daejeon, Republic of Korea;3. Natural Product Research Center, Korea Institute of Science and Technology (KIST), Gangneung, Ganwon‐do, Republic of Korea;4. Lab of Bioimaging Probe Development, Singapore Bioimaging Consortium (SBIC), 11 Biopolis Way, #02‐02 Helios, Agency for Science, Technology and Research (A*STAR), Singapore;5. College of Pharmacy, Sunchon National University, Sunchon, Republic of Korea;6. Department of Chemistry and Medicinal Chemistry Program, National University of Singapore (NUS), Singapore, Singapore |
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| Abstract: | Synthetic molecules that modulate and probe biological events are critical tools in chemical biology. Utilizing combinatorial and diversity‐oriented synthetic strategies, access to large numbers of small molecules is becoming more and more feasible, and research groups in this field can take advantage of the power of chemical diversity. Since the majority of early studies were focused on the discovery of compounds that perturb protein functions, diversity‐based approaches are often considered as therapeutic lead discovery tactics. However, the diversity‐oriented approach can also be applied to advance distinct aims, such as target protein identification, or the development of imaging probes and sensors. This review provides a personal perspective of the chemical‐diversity‐based approach and how this principle can be adapted to various chemical biology studies. |
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| Keywords: | fluorescent probes high‐throughput screening molecular diversity sensors target identification |
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