trans-4-Hydroxy-l-proline: a novel starting material for N-alkylpyrroles synthesis |
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| Authors: | A. Vijay KumarK. Rama Rao |
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| Affiliation: | Organic Chemistry Division-I, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500607, India |
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| Abstract: | The reaction of aldehydes with trans-4-hydroxy-l-proline was studied for the first time, resulting in the formation of N-alkylpyrroles in good to excellent yields, via decarboxylation followed by redox isomerization under neutral conditions. The neutral conditions allow access to efficient synthesis of N-alkyl pyrroles with high functional group tolerance. |
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| Keywords: | Aldehydes Azomethine ylide N-alkyl pyrroles Redox isomerization trans-4-Hydroxy- smallcaps" >l-proline |
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