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Highly stereoselective prins cyclization of (Z)- and (E)-gamma-brominated homoallylic alcohols to 2,4,5,6-tetrasubstituted tetrahydropyrans
Authors:Liu Feng  Loh Teck-Peng
Affiliation:Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637616.
Abstract:An efficient method has been developed to construct 2,6-cis-4,5-dibromo-tetrasubstituted tetrahydropyran (THP) rings with well-controlled stereochemistry in moderate to high yields.
Keywords:
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