A supramolecular nanovehicle toward systematic,targeted cancer and tumor therapy
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| Authors: | Ruizheng Liang Shusen You Lina Ma Chunyang Li Rui Tian Min Wei Dan Yan Meizhen Yin Wantai Yang David G Evans Xue Duan |
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| Institution: | a State Key Laboratory of Chemical Resource Engineering , Beijing Laboratory of Biomedical Materials , Beijing University of Chemical Technology , Beijing 100029 , P. R. China . Email: ; Email: ; Fax: +86-10-64425385 ; Tel: +86-10-64412131 ; b Beijing Shijitan Hospital , Capital Medical University , Beijing 100038 , P. R. China . Email: |
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| Abstract: | A supramolecular nanovehicle (denoted as SNV) was fabricated by encapsulating zinc phthalocyanine (ZnPc) and doxorubicin (DOX) into a copolymer (PVP-b-PAA-g-FA), so as to achieve systematic and synergistic chemotherapy-photodynamic therapy (PDT), targeted tumor imaging and therapy. The sophisticated copolymer designed in this work can load the PDT photosensitizer (ZnPc) and chemotherapy drug (DOX) simultaneously, which exhibits an excellent performance in chemotherapy-PDT targeted cancer and tumor therapy for both in vitro studies performed with HepG2 cells and in vivo tests with mice. This work provides a new drug formulation with a chemotherapy-PDT synergistic effect by virtue of the supramolecular material design, which possesses the advantages of an ultra-low drug dosage and highly-efficient in vivo targeted tumor imaging/therapy. |
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