DNA-based supramolecular hydrogels: From construction strategies to biomedical applications |
| |
| Institution: | 1. Jiangsu Engineering Laboratory for Environmental Functional Materials, Jiangsu Key Lab for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, China;2. School of Chemical Science and Engineering, Shanghai Research Institute for Intelligent Autonomous Systems, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, Shanghai 200092, China;3. Department of Chemistry, Renmin University of China, Beijing 100872, China;1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China;2. Key Laboratory of Biological Nanotechnology of National Health Commission, Changsha 410008, China;1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China;2. Sichuan Provincial Engineering Research Center of Oral Biomaterials, Chengdu, 610041, China;3. Department of Head and Neck Oncology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China;1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China;2. Changsha Medical University, Academician Workstation, Changsha 410219, China;3. Key Laboratory of Biological Nanotechnology of National Health Commission, Changsha 410008, China;1. College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), Nanjing University of Posts & Telecommunications (NJUPT), Nanjing 210023, China;2. Institute of Advanced Materials (IAM) & Institute of Flexible Electronics (Future Technology), Nanjing University of Posts & Telecommunications (NJUPT), Nanjing 210023, China |
| |
| Abstract: | DNA-based supramolecular hydrogels are important and promising biomaterials for various applications due to their inherent biocompatibility and tunable physicochemical properties. The three-dimensional supramolecular matrix of DNA formed by non-covalently dynamic cross-linking provides exceptional adaptability, self-healing, injectable and responsive properties for hydrogels. In addition, DNA hydrogels are also ideal bio-scaffold materials owing to their tissue-like mechanics and intrinsic biological functions. Technically, DNA can assemble into supramolecular networks by pure complementary base pairing; it can also be combined with other building blocks to construct hybrid hydrogels. This review focuses on the development and construction strategies of DNA hydrogels. Assembly and synthesis methods, diverse responsiveness and biomedical applications are summarized. Finally, the challenges and prospects of DNA-based supramolecular hydrogels are discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
