Regulating signal enhancement with coordination-coupled deprotonation of a hydrazone switch
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| Authors: | Justin T Foy Debdas Ray Ivan Aprahamian |
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| Institution: | a SAMS Research Group , University of Strasbourg , Institut Charles Sadron , CNRS , 23 rue du Loess, BP84047 , 67034 , Strasbourg Cedex 2 , France ;b Department of Chemistry , School of Natural Sciences , Shiv Nadar University , Chithera, Tehsil Dadri , Gautam Budh Nagar-203207 , Uttar Pradesh , India ;c Department of Chemistry , Dartmouth College , 6128 Burke Laboratory , Hanover , NH , USA 03755 . Email: |
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| Abstract: | Proton relay plays an important role in many biocatalytic pathways. In order to mimic such processes in the context of molecular switches, we developed coordination-coupled deprotonation (CCD) driven signaling and signal enhancement sequences. This was accomplished by using the zinc(ii)-initiated CCD of a hydrazone switch to instigate an acid catalyzed imine bond hydrolysis that separates a quencher from a fluorophore thus leading to emission amplification. Because CCD is a reversible process, we were able to show that the catalysis can be regulated and turned “on” and “off” using a metalation/demetalation cycle. |
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